All successful drug discovery is underpinned by a suite of robust assays that deliver reliable, robust data to drive project progression. At Charles River Laboratories, teams in the Discovery unit based at Chesterford Park and Harlow are developing and optimising over 100 bespoke in vitro biology assays per year for routine profiling, HTS and beyond. Liquid handling automation is at the heart of all assay development and screening at CRL, and in this short presentation the presenters will show how the Certus Flex has been a popular addition to the lab to achieve aggressive timelines and minimize reagent usage